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Background and study aims Malaria is a tropical disease spread by mosquitoes. It affects up to million people each year, killing million, mostly pregnant women and children in sub-Saharan Africa. The HIV pandemic disproportionately affects sexually active women in Africa, who as a result are more vulnerable to malaria. Infection with both malaria and HIV during pregnancy leads to anaemia decreased red blood cells , low birth weight, and increased risk of death.
CMX has been proven to protect children and HIV-positive adults against malaria, and CMX alone may be effective at preventing malaria during pregnancy. Who can participate? HIV-positive pregnant women aged 15 to 45 What does the study involve? Women are followed up monthly and are asked to deliver in the study center. At delivery a sample of the placenta is collected.
Babies are followed up until the age of 3 months. The number of malaria cases, pregnancy outcome and birth weights are measured in both groups. What are the possible benefits and risks of participating? All treatments and tests are free of charge. All pregnant women receive a mosquito net treated with insecticide.
The main side effects of the study drugs are anaemia and skin allergy. Where is the study run from? When is the study starting and how long is it expected to run for?
January to August Who is funding the study? Dr Elise Klement eklement altersante. Cotrimoxazol is non inferior to standard intermittent preventive treatment IPT on malaria risk in Human immunodeficiency virus HIV pregnant women in rural sub-Saharan Africa.